Peer Reviewed: SELDI-TOF MS for Diagnostic Proteomics
نویسندگان
چکیده
منابع مشابه
A proteomic (SELDI-TOF-MS) approach to estrogen agonist screening.
A small fish model and surface-enhanced laser desorption/ionization time-of-flight mass spectrometry were used to investigate plasma protein expression as a means to screen chemicals for estrogenic activity. Adult male sheepshead minnows (Cyprinodon variegatus) were placed into aquaria for seawater control, solvent control, and treatments of 17beta-estradiol (E2), methoxychlor (MXC), bisphenol-...
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Mass spectrometry from clinical specimens is used in order to identify biomarkers in a diagnosis. Thus, a reliable method for both feature selection and classification is required. A novel method is proposed to find biomarkers in SELDI-TOF in order to perform robust classification.The feature selection is based on a new genetic algorithm. Concerning the classification, a method which takes into...
متن کاملSerum biomarker screening for the diagnosis of early gastric cancer using SELDI-TOF-MS.
In this study, we performed a proteomic analysis of sera from stage I gastric cancer patients using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and established a diagnostic model for the early diagnosis of stage I gastric cancer. Serum samples from 169 gastric cancer patients and 83 age- and gender-matched healthy individuals were analyzed by SEL...
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In search for novel markers for breast cancer, we aimed to identify and validate novel serum protein profiles specific for breast cancer, and assess the influence of clinical (subjects age) and pre-analytical (sample storage duration) variables on the constructed classifiers. To this end, sera of breast cancer patients (n=152) and healthy controls (n=129), randomly divided into a training and t...
متن کاملEstablishment of serum protein pattern for screening colorectal cancer using SELDI-TOF-MS.
AIM The purpose of this study is to develop a proteomic pattern for distinguishing individuals with colorectal cancer from healthy controls and monitoring micrometastasis using SELDI-TOF-MS. METHODS A training set consisting of 63 patients with colorectal cancer, 20 patients with benign colorectal diseases and 26 healthy volunteers was used to develop a proteomic model that discriminated colo...
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ژورنال
عنوان ژورنال: Analytical Chemistry
سال: 2003
ISSN: 0003-2700,1520-6882
DOI: 10.1021/ac031249c